mammary tumour virus

mammary tumour virus
(= Bittner agent)
Retrovirus that induces mammary carcinoma in mice. Isolated from highly inbred strains that had very high incidence of the tumours, after the discovery that the disease was transmitted in milk by nursing mothers. Endogenous provirus is present in germ-line of all inbred mice. Transcription of the provirus is regulated by a viral promoter that increases transcription in response to glucocorticoid hormones. May transform by proviral insertion activating the cellular < int-1>> oncogene.

Dictionary of molecular biology. 2004.

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